Καθηγητής
Πανεπιστήμιο Ιωαννίνων
e-mail: kskobrid@cc.uoi.gr
Τηλέφωνο: ( +30) 26510 08598
Fax: (+30) 26510 08670
Education-Career/Employment
1987: B.S., Chemistry, Chemistry Department, Rheinische Friedrich Wilhelms University of Bonn, Germany
1991: Ph.D., Chemistry, Chemistry Department, Rheinische Friedrich Wilhelms University of Bonn, Germany
1992-1993: Postdoc (Professor D. Seebach), Eidgenössische Technische Hochshule (ETH) Zürich, Schwitzerland
1993-1995: Central Research Laboratories, Ciba, Basel, Schwitzerland
1996-2001: General Chemical State Laboratory of Greece, Ioannina, Greece
2001-2005: Lecturer, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece
2006-2010: Assistant Professor, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece
2010-2016: Associate Professor, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece
since 2016: Professor, Section of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, Greece
Awards-Fellowships
1987-1988: Theodorr-Laymann-Stiftung diploma thesis fellowship (with Prof. E. Weber)
1989-1991: Konrad-Adenauer-Stiftung PhD fellowship (with Prof. E. Weber)
1992-1993: Deutsche Forschungsgemeinschaft (DFG) postdoctoral fellowship (with Prof. D. Seebach, ETH Zurich)
Research
– Design, synthesis, characterization (1H-NMR, MS, etc), properties and applications of host-guest inclusion compounds.
– Macromolecules. Design and synthesis of dendrimers and dendrimer conjugates with calixarens, crown-ethers, etc, properties and applications.
– Design and synthesis of novel organic compounds with biological activity. Selective inhibitors of protein kinases.
– Development of new synthetic methods. Mechanistic studies of organic reactions
Teaching
Undergraduate
Organic Chemistry II,IV,V, Laboratory of Organic Chemistry I and II, Literature and Laboratory Research
Graduate
Advanced Lectures in Organic Chemistry (Retrosynthetic Analysis), Structure and Mechanisms in Organic Chemistry
List of selected publications
1. E. Weber, K. Skobridis, M. Ouchi, T. Hakushi and Y. Inone
Polytropic Cation Receptors. Di- and Triloop Crown Hosts Having Aromatic Junctions. Synthesis, Cation Extraction, and Solid Complex Formation. Bull. Chem. Soc. Jpn., 1990, 63 (12), 3670-3677.
2. E. Weber, K. Skobridis, A. Wierig, S. Stathi and L. R. Nassimbeni
A New Atropisomeric Molecular Structure for Efficient Enantiodifferentiation
Angew. Chem. Int. Ed. Engl. 1993, 32 (4), 606-608.
3. J.-M. Lapierre, K. Skobridis and D. Seebach
Preparation of Chiral Building Blocks for Starburst Dendrimer Synthesis. Helv. Chim. Acta 1993, 76 (7), 2419-2432.
4. D. Seebach, J.-M. Lappiere, K. Skobridis and G. Greiveldinger
Chiral Dendrimers from Tris(hydroxymethyl)-methane Derivatives, Angew. Chem. Int. Ed. Engl. 1994, 33 (4), 440-442.
5. D. Seebach, J.-M. Lapierre, G. Greiveldinger and K. Skobridis
Synthesis of Chiral Starburst Dendrimers from PHB-Derived Triols as Central Cores. Helv. Chim. Acta 1994, 77 (7), 1673-1688.
6. V. Thedorou and K. Skobridis
An Unexpected Base-induced Rearrangement of Tritylamine. Tetrahedron Lett. 2005, 46 (30), 5021-5023.
7. K.Skobridis, D. Hüsken, P. Nicklin and R. Häner
Hybridization and Cellular Uptake Properties of Lipophilic Oligonucleotide-dendrimer Conjugates”. Arkivoc 2005, part(vi), 459-469.
8. K. Skobridis, V. Theodorou and E. Weber
A Very Simple and Chemoselective Air Oxidation of Benzoins to Benzils by Use of Alumina. Arkivoc 2006, part(x), 102-106.
9. D. Alivertis, V. Theodorou, G. Paraskevopoulos, K. Skobridis
Searching for new host compounds: synthesis and characterization of novel crown ether-functionalized dendrimers. Tetrahedron Lett. 2007, 48 (23), 4091-4095.
10. V. Theodorou, K. Skobridis, A. Karkatsoulis
Base-induced rearrangement of tritylamines to imines: discovery and investigation of the mechanism. Tetrahedron 2007, 63 (20), 4284-4289.
11. V. Theodorou, K. Skobridis, A.G. Tzakos, V. Ragoussis
A simple method for the alkaline hydrolysis of esters. Tetrahedron Lett. 2007, 48 (46), 8230-8233.
12. Alivertis, G. Paraskevopoulos, V. Theodorouand, K. Skobridis
Dendritic effects of crown ether-functionalized dendrimers on the solvent extraction of metalions. Tetrahedron Lett. 2009, 50 (44), 6019-6021.
13. V. Theodorou, A. Karkatsoulis, M. Kinigopoulou, V. Ragoussis, K. Skobridis
Tritylamine as an ammonia synthon: Preparation of primary amides. Arkivoc 2009, part (xi), 277-287.
14. K. Skobridis, M. Kinigopoulou, V. Theodorou, E. Giannousi, A. Russell, R. Crozier, N. Brownlow, S. Kiriakidis, J. Domin, A. Tzakos, N. J. Dibb
Novel imatinib derivatives with altered specificity for Bcr-Abl and FMS, KIT, and PDGF receptors. Chem. Med.Chem. 2010, 5(1), 130-139.
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